洪烨 教授

E-Mail：hongye@sdu.edu.cn

个人简介

洪烨，山东大学齐鲁青年学者，博士生导师。

教育背景

2005.9-2011.6  山东大学 微生物技术国家重点实验室 博士

2010.1-2011.1  德国马克思普朗克陆地微生物研究所  国家高水平公派研究生

2001.9-2005.6  山东大学 生物技术专业 本科

工作经历

2019.3-至今  山东大学 教授

2017.05-2019.3  英国医学研究理事会蛋白磷酸化与泛素化研究中心 高级研究助理

2011.09-2017.05 英国邓迪大学基因调控与表达研究中心 博士后

科研方向

本课题组以模式生物秀丽隐杆线虫为主要研究对象，综合利用细胞生物学，遗传学，分子生物学，基因编辑以及下一代基因组测序技术等手段，从事与人类疾病发生密切相关的DNA损伤修复机制的研究。

主持课题

2019-2024，DNA损伤修复和基因组稳定性维持，山东大学“齐鲁青年学者”建设经费

2020-2022，核酸酶LEM-3的生化性质与体内功能研究，国家自然科学基金青年基金

本课题组长期招聘博士后研究人员！欢迎联系！

研究成果

1.Hong Y, Sonneville R, Wang B, Woglar A, Labib K, Jantsch V, Gartner A. LEM-3 is a midbody- tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nature Communications, 9, 728 (2018)

2.Hong Y, Velkova M, Silva N, Jagut M, Scheidt V, Labib K, Jantsch V and Gartner A. The conserved LEM-3/Ankle1 nuclease is involved in meiotic recombination and chromosome segregation in Caenorhabditis elegans. PLoS Genet (2018) 14(6): e1007453.

3.Meier B, Volkova N, Hong Y, Schofield P, Campbell PJ, Gerstung M, Gartner A. Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers. Genome Research 2018, 28(5):666-675

4.Bertolini S, Wang B, Meier B, Hong Y, Gartner A. Caenorhabditis elegans BUB-3 and SAN- 1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation. G3 (Bethesda). (2017) 4;7(12):3875-3885.

5.Hong Y, Sonneville R, Agostinho A, Meier B, Wang B, Blow J, Gartner A. The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during C. elegans meiosis. PLoS Genet (2016) 24;12(3):e1005

6.Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U; Biallelic Mismatch Repair Deficiency Consortium. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat Genet. (2015), 3, 257-262

7.Vassart A, Van Wolferen M, Orell A, Hong Y, Peeters E, Albers SV, Charlier D. Sa-Lrp from Sulfolobus acidocaldarius is a versatile, glutamine-responsive, and architectural transcriptional regulator. Microbiologyopen (2013). 2:75-93.

8.Hong Y, Wang Z, Zhang Z, Ma X, Ni J, Sheng D, Shen Y. Dissection of the functional domains of an archaeal Holliday junction helicase. DNA repair. (2012), 2, 102-111

9.Ma X, Hong Y, Han W, Sheng D, Ni J, Hou G, Shen Y. Single-stranded DNA binding activity of XPBI, but not XPBII, from Sulfolobus tokodaii causes double-stranded DNA melting. Extremophiles.(2011) 15, 67-76.

10.Wu L, Liu B, Hong Y, Sheng D, Shen Y, Ni J. Residue Tyr224 is critical for the thermostability of

Geobacillus sp. RD-2 lipase. Biotechnol Lett. (2010),32,107-112.

11.Liu B, Wu L, Liu T, Hong Y, Shen Y, Ni J.A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties. Biotechnol Lett. (2009),31(12):1937-1941.

12.Hong Y, Wu L, Liu B, Peng C, Sheng D, Ni J, Shen Y. Characterization of a glucan phosphorylase from the thermophilic archaeon Sulfolobus tokodaii strain 7.J. Mol. Catal. B: Enzy. (2008), 54, 27-34

13.Liu B, Hong Y, Wu L, Li Z, Ni J, Sheng D, Shen Y A unique highly thermostable 2- phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshii: gene cloning, expression and characterization. Extremophiles. (2007), 11(5): 733-739.

14.Liu B, Li Z, Hong Y, Ni J, Sheng D, Shen Y. Cloning, expression and characterization of a thermostable exo-beta-D-glucosaminidase from the hyperthermophilic archaeon Pyrococcus horikoshii. Biotechnol Lett. 2006, 28(20): 1655-1660.