刘相国 教授 

电话：0532-58630878

E-mail: xgliu at sdu dot edu dot cn

学术网页

https://webofscience.clarivate.cn/wos/author/record/JPX-7213-2023

https://www.researchgate.net/profile/Xiangguo-Liu-2

教育经历

1990.9-1994.7 山东大学生物系            理学学士学位（生物学）

1994.9-1997.7365bet  理学硕士学位（细胞生物学）

1997.9-2000.7中国科学院微生物研究所 理学博士学位（微生物学）

工作经历

2000.9-2002.11，北京大学医学部基础医学院免疫系 博士后

2002.11-2003.8，美国University of Florida医学院 博士后

2003.9-2008.8，美国Emory大学Winship Cancer Institute 博士后

2008.10-现在， 365bet 教授，博导

研究方向

1.细胞焦亡、凋亡及自噬的调控机制

2.肿瘤免疫治疗机制

3.mRNA疗法等生物医药技术

代表性论文：

1.Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L*, Liu X*. Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. Cell Death Dis. 2023;14(9):645.

2.Wang Y, Wei M, Su M, Du Z, Dong J, Zhang Y, Wu Y, Li X, Su L*, Liu X*. DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells. iScience, 2023; 26(7):107157.

3.Xu L, Shi F, Wu Y, Yao S, Wang Y, Jiang X, Su L*, Liu X*. Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells. Cell Commun Signal. 2023;21(1):83.

4.Yao S, Shi F, Mu N, Li X,Ma G,Wang Y, Sun X, Liu X*, Su L*. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. Cancer Lett. 2021; 502:1-8.

5.Wang Y, Sun Q, Mu N, Sun X, Wang Y, Fan S, Su L*, Liu X*.The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells. Cell Commun Signal. 2020;18(1):112.

6.Wang Y, Guo S, Li D, Tang Y, Su L*, Liu X*. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells. Cell Death Dis. 2020; 11(4):242.

7.An W, Yao S, Sun X, Hou Z, Lin Y*, Su L*, Liu X*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):181.

8.Li M, An W, Xu L, Lin Y, Su L*, Liu X*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):64.

9.Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.

10.Liu X, Su L*, Liu X*. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587:3995-4000.

11.Li T, Su L, Zhong N, Hao X, Zhong D, Singhal S, Liu X*. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.

12.Xu L, Su L, Liu X*. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012; 11(10):2174-82.

13.Su L, Liu G, Hao X, Zhong N, Zhong D, Liu X*, Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer. 2011; 47(16):2471-8.

14.Oh YT#, Liu X#, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY.ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010; 285(53): 41310-41319.

15.Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007; 67 (10):4981-8.

16.Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006; 66(23):11115-9.

17.Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005; 65(20): 9169-75.

18.Jin F#, Liu X#, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005; 65(14):6354-63.

19.Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004; 96(23): 1769-80.

20.Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004; 64(15): 5078-83.

荣誉和奖励

教育部新世纪优秀人才基金，2009

山东省自然科学杰出青年基金，2010

泉城产业领军人才，2017

青岛即墨区拔尖人才，2020