汪正品：博士，研究员，博士生导师

山东大学“齐鲁青年学者”，山东省优秀青年科学基金项目（海外）获得者

E-mail：zhengpin.wang@sdu.edu.cn

教育背景

2008.09-2014.06 中国农业大学 生物学院 理学博士 导师：夏国良教授

2004.09-2008.06 华中农业大学 水产学院 农学学士

工作经历

2021.09-至今 山东大学 365bet 研究员

2015.02-2021.07 NIDDK 美国国立卫生研究院（NIH） 博士后 导师：Jurrien Dean

研究方向

长期从事哺乳动物配子发生发育的相关研究工作，目前以第一作者/通讯作者身份在Nature Communications，Nucleic Acids Research，Journal of Biological Chemistry等杂志发表多篇生殖领域研究论文。应邀担任The FASEB Journal，Journal of Urology，Scientific Reports，Archives of Virology等杂志审稿人。曾荣获NIH Nancy Nossal Fellowship Award，NIH Fellows Award for Research Excellence (FARE)等奖励。实验室主要通过基因编辑技术构建小鼠模型，结合细胞生物学、发育生物学、生物化学以及生物信息学等手段，研究遗传因素在配子发生发育过程中的分子调控机制。

具体研究内容包括：

1.原始卵泡形成，卵泡发育的分子调控机理。

2.精原干细胞维持和分化的分子调控机制。

3.精母细胞减数分裂的分子调控机制。

4.精子发育成熟的分子调控机制。

主持课题

2024.01-2027.12，核糖核酸酶DIS3调控小鼠精子发生与雄性生育力的分子机制研究，国家自然科学基金面上项目

2023.01-2025.12，核糖核酸酶DIS3L2在精子发生与雄性不育中的功能研究，山东省自然科学基金面上项目

2022.04-2025.04，精子发生与雄性不育，山东省优秀青年科学基金项目（海外）

2021.10-2026.10，精子发生与雄性不育的分子机制研究，山东大学“齐鲁青年学者”建设经费

代表性论文（*为通讯作者）

1.Li N, Yu J, Zhou M, Qiu F, Wang X, Zhengpin Wang*; MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice, Biochem Biophys Res Commun, 2023, 10;675:46-53.

2.Qiu F, Wang X, Zhou M, Yu J, Zhengpin Wang*; Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility, Biochem Biophys Res Commun, 2023, 23;666:36-44.

3.Wang X, Qiu F, Yu J, Zhou M, Zuo A, Xu X, Sun XY, Zhengpin Wang*; Transcriptome profiling of the initial segment and proximal caput of mouse epididymis, Frontiers in Endocrinology, 2023, 14:1190890.

4.Zhengpin Wang; Xiaojiang Xu*; scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells, Cells, 2020, 9(4): 920.

5.Zhengpin Wang*; Chen-Yu Liu; Yangu Zhao; Jurrien Dean*; FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation, Nucleic Acids Research, 2020, 48(7): 3525-3541.

6.Zhengpin Wang*; Xiaojiang Xu; Jian-Liang Li; Cameron Palmer; Dragan Maric; Jurrien Dean*; Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice, Nature Communications, 2019, 10(1): 5196.

7.Zhengpin Wang; Wanbao Niu; Yijing Wang; Zhen Teng; Jia Wen; Guoliang Xia; Chao Wang*; Follistatin288 regulates germ cell cyst breakdown and primordial follicle assembly in the mouse ovary, PLoS ONE, 2015, 10(6): e0129643.

8.Zhengpin Wang; Xinyi Mu; Meng Guo; Yijing Wang; Zhen Teng; Guanping Mao; Wanbao Niu; Lizhao Feng; Lihua Zhao; Guoliang Xia*; Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary, Journal of Biological Chemistry, 2014, 289(12): 8299-8311.

9.Heejin Choi*; Zhengpin Wang; Jurrien Dean*; Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA, PLoS Genetics, 2021, 17(4): e1009485.

10.Xinyi Mu; Jia Wen; Qian Chen; Zhengpin Wang; Yijing Wang; Meng Guo; Yi Yang; JinRui Xu; Zhiqing Wei; Guoliang Xia; Mengye Yang; Chao Wang*; Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice, Biology Open, 2018, 7(11): bio035626.

11.Meng Guo; Cheng Zhang; Yan Wang; Lizhao Feng; Zhengpin Wang; Wanbo Niu; Xiaoyan Du; Wang Tang; Yuna Li; Chao Wang*; Zhenwen Chen*; Progesterone receptor membrane component 1 mediates progesterone-induced suppression of oocyte meiotic prophase I and primordial folliculogenesis, Scientific Reports, 2016, 6(1): 1-14.

12.Wanbao Niu; Ye Wang; Zhengpin Wang; Qiliang Xin; Yijing Wang; Lizhao Feng; Lihua Zhao; Jia Wen; Hua Zhang; Chao Wang; Guoliang Xia*; JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice, Development, 2016, 143(10): 1778-1787.

13.Yijing Wang; Zhen Teng; Ge Li; Xinyi Mu; Zhengpin Wang; Lizhao Feng; Wanbao Niu; Kun Huang; Xi Xiang; Chao Wang; Hua Zhang*; Guoliang Xia*; Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary, Development, 2015, 142(2): 343-351.

14.Cheng Zhang*; Xiaoxia Wang; Zhengpin Wang; Wanbao Niu; Baochang Zhu; Guoliang Xia*; Effect of different culture systems and 3, 5, 3'-triiodothyronine/follicle-stimulating hormone on preantral follicle development in mice, PLoS ONE, 2013, 8(4): e61947.

15.Xinyi Mu; Jing Wen; Meng Guo; Jianwei Wang; Ge Li; Zhengpin Wang; Yijing Wang; Zhen Teng; Yan Cui; Guoliang Xia*; Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells, Journal of Cellular Physiology, 2013, 228(3): 627-639.

16.Cheng Zhang; Wanbao Niu; Zhengpin Wang; Xiaoxia Wang*; Guoliang Xia*; The effect of gonadotropin on glucose transport and apoptosis in rat ovary, PLoS ONE, 2012, 7(8): e42406.

课题组长期招聘博士后，同时欢迎对发育生物学和生殖生物学感兴趣的同学报考硕士和博士。